When our bodies are under attack by pathogens or other foreign particles that are perceived to be harmful, an immune response is sparked to eliminate the invaders. Our immune systems have evolved a variety of tricks to help identify these attackers and then recruit special cells to the sites of attack that can destroy them and protect the body. One such protective response is the allergic response, though in these cases, the body is overreacting to the invasion of something harmless, sending the immune system into overdrive. Thus, allergies belong to a category of immune responses known as hypersensitivity.
Upon recognizing the allergen as an intruder, the body sends in immune cells called T helper cells. These T helper cells secrete signaling molecules that recruit other immune cells to help deal with the attacker, including B cells, which are stimulated to produce an antibody called IgE. The IgE antibodies made are specifically responsive to the allergen — they recognize it and bind it. Once antibodies are bound to the allergen, they can stimulate the production of molecules called histamines. Histamines alter the cells in the capillaries to allow white blood cells and other immune cells through so that they may eliminate the attacker. This also causes the inflammation (redness and swelling) associated with this part of the immune response, which the root of many symptoms associated with allergies.
Because the IgE molecules specific to the antigen can continue to circulate in the body, this also gives the immune system a sort of memory for what it has been exposed to. This immunological memory is the basis of many vaccines, which provide a measured exposure of a potential attacker, so that the body can very quickly respond to it if it is encountered again in life. Allergens provoke an unusually strong response, however, and why this hypersensitivity occurs in some people and not others is unclear.
Allergy symptoms vary depending on where the allergen enters the body and the strength of the allergic reaction that occurs. Symptoms may include:
If allergies are mild, they may pose little other risk beyond annoyance for the sufferer. Chronic allergies, such as seasonal allergies, may keep a person’s immune system in overdrive, however, which can be very exhausting and potentially make them more susceptible to other illnesses and infections. The immune system has limited resources, so if its response is diverted toward something inconsequential, like pollen, they may not be able to adequately fight off pathogens and other infections.
The chronic inflammation associated with allergies can be damaging to tissues, as well, increasing the possibilities of outside infection. Many chronic allergy sufferers also endure frequent sore throats, sinus infections, and skin problems.
If the allergic response very suddenly triggers a massive release of histamines into the body, the rapid permeabilization of all the blood vessels can cause a devastating drop in blood pressure and release fluids into the lungs, making it difficult to breathe. There can be swelling of the face, neck, and throat, additionally obstructing breathing, and a person may also have convulsions. This extreme hypersensitivity response, called anaphylaxis, is a whole-body allergic reaction that can be fatal if not treated immediately.
Specifically, allergies are caused by the allergens the body encounters. Many allergens are airborne, inducing the allergic response as they come into contact with the eyes, noses, mouths, and lungs upon inhalation. Seasonal allergies are caused by pollen, and people may also develop allergies to dust, mold, insect stings, medications, and certain foods. Contact of an allergen with the skin can also potentially provoke an allergic response, as is the case with latex allergies.
In better developed areas, the body is exposed to more pollutants and industrial byproducts, which could possibly make the body more sensitive to allergens. Overall, however, epidemiological data suggests a much lower incidence of autoimmune and immunological disorders in the developing world. This has lead to the hygiene hypothesis, which instead suggests that challenges to a young child’s immune system actually have long term benefits. By exposing the immune system to allergens and pathogens early in life, it is strengthened and also better tuned such that it will not over-respond, as in the case of the allergic response. Some proponents of this theory add that certain pathogens and parasites ingested as a part of less “clean” living conditions may also be a benefit, as they effectively reduce what might otherwise be an overzealous immune response.
Diagnosis of specific allergies is generally done using skin tests or blood tests. If possible, it is recommended that people with allergies make efforts to avoid their allergens. In cases where this is not possible (as with seasonal allergies), then there are many drugs available to help quell the overactive immune response. Antihistamines, for example, can disrupt the histamine response responsible for initiating many of the symptoms. Cortisone, hydrocortisone, dexamethasone, and epinephrine are also useful for suppressing the immune response during an allergic reaction. During an anaphylactic response, decongestants, anti-cholinergics, and mast cell stabilizers (which will decrease histamine release) may also be used to relieve the symptoms.
We know that allergies can make you feel miserable, particularly if the allergens are difficult to avoid, leaving you in a chronic state of discomfort. We will help you identify the allergens through blood testing and as appropriate, help devise a treatment plan specific to your allergen profile.
As part of your treatment, we may prescribe natural supplements that will support a healthy immune response and respiratory health. Herbal supplements containing quercetin, bromelain and stinging nettles improve respiratory health by relieving allergy symptoms in the lungs, sinus, and nasal passages. The anti-inflammatory activities of omega-6 fatty acid may help calm the immune response and reduce allergy symptoms.
A complete evaluation and comprehensive review is completed for each patient. Our doctors and professionals will evaluate your results and will spend one on one time with you to interpret and explain your results. Together we will explore your goals and discuss your treatment plan options. These treatment plans can be implemented using multiple modalities such as medications, hormones, diet, supplements, behavior and lifestyle changes, and alternative therapies. Our doctors will prescribe a preventative and comprehensive treatment plan that is tailored to your needs and fits into your lifestyle. Our team at The Center for Natural & Integrative Medicine will regularly monitor your progress and track the effectiveness of your program making adjustments if necessary. Our goal is to support you and advise you every step of the way. We work in conjunction with your existing doctors to ensure the best possible care.
Our immune systems are designed to protect us from pathogens and other foreign particles that may do us harm. Upon sensing an intrusion, the body sends specialized cells that can fight and kill the offending particle by inducing the inflammation response. Normally, the immune response is appropriate to the level of threat.
The allergic response, however, is an overreaction by the immune system, normally in response to something that is not particularly harmful, such as dust or pollen. People can also develop allergies to particular foods, which can cause a severe allergic reaction upon ingestion. The incidence of food allergies has increased dramatically over the years, and it is estimated that up to 20% of the population have adverse reactions to foods. Our hyperactive immune system is mistakenly identifying foods and environmental proteins as foreign invaders such as bacteria, fungus and viruses.
Food allergies in children can impact their growth and development if the sources are not identified and eliminated quickly. Mild food allergies in adults may be reasonably tolerated, the symptoms perhaps confused with food poisoning or illness-related gastrointestinal distress. Clearly, if a person is sensitive enough to the food that anaphylactic shock is a probability, special care must be taken to avoid eating, touching, or smelling the food, as anaphylaxis may be fatal.
An allergic reaction to food can occur within seconds of consuming the food or may take an hour to develop. Symptoms include:
In the case of a severe food allergy that induces anaphylactic shock, a person may experience:
Increased total antigenic load related to food and environmental sensitivities has been associated with a wide range of medical conditions affecting virtually every part of the body. Even mood and behavior, including hyperactivity disorders in children, are profoundly influenced by food allergies. Symptoms can range from mildly uncomfortable to severe and may include:
Over 90% of the food allergies in the United States are caused by the same eight food types. These include:
Some common food chemicals can also induce allergic responses, such as sulfites, which are commonly used as preservatives in wine, dried fruits, and dried potato products. Food colorings, such as tartrazine (aka Yellow 5), can also aggravate allergies in some people, leading them to avoid food colorings completely. Monosodium glutamate (MSG) is a food additive used to intensify flavor in a variety of soups and sauces that some people also have reactions to. Salicylates found in instant coffee, beer, soy sauce, tomato paste or sauce, honey, and aspirin may also be food allergens in some people.
At The Center for Natural & Integrative Medicine we offer food allergy testing using specialized blood lab testing for up to 300 foods, vegetables, spices, dyes, inhalants, and pollutants. Classical skin testing for allergies such as skin-scratch testing, only measures IgE-mediated reactions and provides no information concerning delayed IgG hypersensitivity reactions. Assessment of relative IgG antibody levels to a multitude of foods using sensitive Enzyme-Linked Immunosorbent Assay (ELISA) technology identifies those foods against which the patient is producing antibodies. Measuring both relative IgE and IgG antibody levels provides an invaluable starting point for dietary intervention. This test helps to identify those with true immune-mediated allergies versus food intolerance. It measures IgG antibody levels and IgE.
The key differences between IgE and IgG mediated allergies are summarized below:
|IgE Mediated Allergies
Immediate onset (within minutes)
Circulating half life of 1-2 days
Stimulates histamine release
Includes foods, inhalants & molds
|IgG Mediated Allergies
Delayed onset (4-72 hours)
Circulating half life of 21 days
Stimulates histamine release
Includes foods, herbs & spices
The results of the test come with a detailed explanation and a suggested avoidance, elimination and subsequent slow reintroduction of foods. We help with menu and food planning. Delayed food sensitivity or intolerances can lead to fatigue, fibromyalgia, brain fog, unexplained aches and pains among other symptoms.
A complete evaluation and comprehensive review is completed for each patient. Our doctors and professionals will evaluate your results and will spend one on one time with you to interpret and explain your results. Together we will explore your goals and discuss your treatment plan options. These treatment plans can be implemented using multiple modalities such as medications, hormones, diet, supplements, behavior and lifestyle changes, and alternative therapies. Our doctors will prescribe a preventative and comprehensive treatment plan that is tailored to your needs and can be integrated into your lifestyle. Our team at The Center for Natural & Integrative Medicine will regularly monitor your progress and track the effectiveness of your program making adjustments if necessary. Our goal is to support you and advise you every step of the way. We work in conjunction with your existing doctors to ensure the best possible care.