A study involving mice infected with Staphylococcus aureus (S. aureus) found that high doses of vitamin B increased immunity to staph bacteria. Results showed that C/EBPe-deficient mice are severely affected by infection with S. aureus, and C/EBPe deficiency in vitamin B contributes to the severity of infection. Vitamin B3 increased expression of C/EBPe in WT myeloid cells. Vitamin B enhanced killing of S. aureus by up to 1,000x but had no effect when administered to either C/EBPe-deficient mice or vitamin B depleted mice. Vitamin B was effective in both therapeutic and preventive circumstances. Results indicate that vitamin B may be able to boost innate immune system.